PD1 blockade with pembrolizumab is highly effective in relapsed or refractory NK/T-cell lymphoma failing l-asparaginase

Key points – NK/T-cell lymphomas failing L-asparaginse, generally fatal, showed a high complete response rate to PD1 blockade with pembrolizumab. Comprehensive clinical, radiologic, pathologic, and molecular assessments showed different patterns of complete response and partial responses.